Open AccessAngiotensin-converting enzyme I/D polymorphism and macrovascular disease in systemic sclerosis
Author(s) -
Francesca Bartoli,
Chiara Angotti,
Cinzia Fatini,
Maria Letizia Conforti,
Serena Guiducci,
Jelena Blagojević,
Daniela Melchiorre,
Ginevra Fiori,
Sergio Generini,
Nemanja Damjanov,
Simona Rednic,
Alberto Moggi Pig,
Sergio Castellani,
Rosanna Abbate,
M Matucci Cerinic
Publication year - 2007
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/kel433
Subject(s) - medicine , genotype , macrovascular disease , gastroenterology , blood pressure , angiotensin converting enzyme , intima media thickness , cardiology , allele , endocrinology , diabetes mellitus , carotid arteries , type 2 diabetes , gene , genetics , biology
Systemic sclerosis (SSc) is characterized by microvascular and macrovascular alterations. The D allele of the ACE I/D polymorphism is known to be associated with an increased incidence of atherosclerosis and has been recently proposed as associated with increased risk of SSc. This study evaluates the relationship between intima-media thickness (IMT), ankle-brachial pressure measurements (ABPI) and ACE I/D polymorphism in SSc patients.