Open AccessPhosphatidylserine IgG and beta-2-glycoprotein I IgA antibodies may be a risk factor for ischaemic stroke
Author(s) -
Timo Kahles,
Marek Humpich,
Helmuth Steinmetz,
Matthias Sitzer,
Edelgard Lindhoff-Last
Publication year - 2005
Publication title -
rheumatology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.957
H-Index - 173
eISSN - 1462-0332
pISSN - 1462-0324
DOI - 10.1093/rheumatology/keh698
Subject(s) - medicine , lupus anticoagulant , stroke (engine) , partial thromboplastin time , antibody , antiphospholipid syndrome , gastroenterology , immunology , thrombosis , pathogenesis , coagulation , mechanical engineering , engineering
Antiphospholipid antibodies (APLA) are established risk factors for venous thrombosis but their role in the pathogenesis of cerebral ischaemia is unclear. The purpose of the present study was to evaluate the relevance of various APLA in patients with cryptogenic stroke (group A, n = 21) and determined causes of stroke (group B, n = 104) according to the TOAST classification in comparison with healthy volunteers without any thrombotic or ischaemic event in their history (group C, n = 84).