A coaxially extruded heterogeneous core–shell fiber with Schwann cells and neural stem cells | Zendy

Xinda Li | Zendy; Dezhi Zhou | Zendy; Zhizhong Jin | Zendy; Hongqing Chen | Zendy; Xuanzhi Wang | Zendy; Xinzhi Zhang | Zendy; Tao Xu | Zendy

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A coaxially extruded heterogeneous core–shell fiber with Schwann cells and neural stem cells

Author(s) -

Xinda Li,

Dezhi Zhou,

Zhizhong Jin,

Hongqing Chen,

Xuanzhi Wang,

Xinzhi Zhang,

Tao Xu

Publication year - 2019

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbz037

Subject(s) - stem cell , fiber , core (optical fiber) , materials science , neuroscience , computer science , nanotechnology , microbiology and biotechnology , biology , composite material

Cellular therapies play a critical role in the treatment of spinal cord injury (SCI). Compared with cell-seeded conduits, fully cellular grafts have more similarities with autografts, and thus might result in better regeneration effects. In this study, we fabricated Schwann cell (SC)-neural stem cell (NSC) core-shell alginate hydrogel fibers in a coaxial extrusion manner. The rat SC line RSC96 and mouse NSC line NE-4C were used in this experiment. Fully cellular components were achieved in the core portion and the relative spatial positions of these two cells partially mimic the construction of nerve fibers in vivo . SCs were demonstrated to express more genes of neurotrophic factors in alginate shell. Enhanced proliferation and differentiation tendency of NSCs was observed when they were co-cultured with SCs. This model has strong potential for application in SCI repair.

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