A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery | Zendy

Boxuan Ma | Zendy; Weihua Zhuang | Zendy; Gongyan Liu | Zendy; Yunbing Wang | Zendy

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A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery

Author(s) -

Boxuan Ma,

Weihua Zhuang,

Gongyan Liu,

Yunbing Wang

Publication year - 2017

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbx023

Subject(s) - micelle , biocompatibility , copolymer , drug delivery , paclitaxel , chemistry , phosphorylcholine , controlled release , nanomedicine , nanotechnology , combinatorial chemistry , materials science , organic chemistry , nanoparticle , polymer , aqueous solution , biochemistry , medicine , surgery , chemotherapy

As nano-scale drug delivery systems, smart micelles that are sensitive to specific biological environment and allowed for target site-triggered drug release by reversible stabilization of micelle structure are attractive. In this work, a biocompatible and pH-sensitive copolymer is synthesized through bridging poly (2-methacryloyloxyethyl phosphorylcholine) (PMPC) block and poly ( D, L -lactide) (PLA) block by a benzoyl imine linkage ( Blink ). Biomimetic micelles with excellent biocompatibility based on such PLA- Blink -PMPC copolymer are prepared as carriers for paclitaxel (PTX) delivery. Due to the rapid breakage of the benzoyl imine linkage under acidic condition, the micelle structure is disrupted with accelerated PTX release. Such pH-sensitive triggered drug release behavior in synchronization with acidic conditions at tumor site is helpful for improving the utilization of drug and facilitating antitumor efficacy. These micelles can be used as promising drug delivery systems due to their biocompatible and smart properties.

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