Hydrogen peroxide detection with high specificity in living cells and inflamed tissues | Zendy

Lei Rong | Zendy; Chi Zhang | Zendy; Qi Lei | Zendy; MingMing Hu | Zendy; Jun Feng | Zendy; HongBing Shu | Zendy; Yi Liu | Zendy; XianZheng Zhang | Zendy

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Hydrogen peroxide detection with high specificity in living cells and inflamed tissues

Author(s) -

Lei Rong,

Chi Zhang,

Qi Lei,

MingMing Hu,

Jun Feng,

HongBing Shu,

Yi Liu,

XianZheng Zhang

Publication year - 2016

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbw022

Subject(s) - hydrogen peroxide , chemistry , fluorescence , chromophore , in vivo , biophysics , in vitro , selectivity , photochemistry , nanotechnology , biochemistry , catalysis , materials science , biology , optics , physics , microbiology and biotechnology

Hydrogen peroxide (H2O2) detection in biological systems is of significant importance, which act as critical second messenger in fundamental biological processes. Here, we report on a chemoselective fluorescent naphthylimide peroxide probe (NPP) for the H2O2 detection in vitro and in vivo. NPP is a phenylboronic acid-caged chromophore that selectively responds to H2O2 through a self-immolate mechanism. NPP exhibited high sensitivity and selectivity to H2O2 with distinctive fluorescence change due to the excellent two-photon excitation property, which permits the facile detection of inflammation produced H2O2 and offers chance to monitor the inflammatory stages in diseased cells.

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