Calcium phosphate nanoparticles-based systems for siRNA delivery | Zendy

Xiaochun Xu | Zendy; Zehao Li | Zendy; Xueqin Zhao | Zendy; Lawrence Jordan Keen | Zendy; Xiangdong Kong | Zendy

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Calcium phosphate nanoparticles-based systems for siRNA delivery

Author(s) -

Xiaochun Xu,

Zehao Li,

Xueqin Zhao,

Lawrence Jordan Keen,

Xiangdong Kong

Publication year - 2016

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbw010

Subject(s) - transfection , liposome , chemistry , nanoparticle , nanotechnology , biophysics , lysosome , intracellular , calcium , biodistribution , surface modification , in vitro , materials science , biochemistry , enzyme , biology , organic chemistry , gene

Despite the enormous therapeutic potential of siRNA as a treatment strategy, the delivery is still a problem due to unfavorable biodistribution profiles and poor intracellular bioavailability. Calcium phosphate (CaP) co-precipitate has been used for nearly 40 years for in vitro transfection due to its non-toxic nature and simplicity of preparation. The surface charge of CaP will be tuned into positive by surface modification, which is important for siRNA loading and crossing cell membrane without enzymatic degradation. The new siRNA carrier system will also promote the siRNA escape from lysosome to achieve siRNA sustained delivery and high-efficiency silence. In this review, we focus on the current research activity in the development of CaP nanoparticles for siRNA delivery. These nanoparticles are mainly classified into lipid coated, polymer coated and various other types for discussion.

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