Silk fibroin/poly (vinyl alcohol) blend scaffolds for controlled delivery of curcumin | Zendy

Xiong Li | Zendy; Jin Qin | Zendy; Jingzhi Ma | Zendy

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Silk fibroin/poly (vinyl alcohol) blend scaffolds for controlled delivery of curcumin

Author(s) -

Xiong Li,

Jin Qin,

Jingzhi Ma

Publication year - 2015

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbv008

Subject(s) - fibroin , vinyl alcohol , silk , scaffold , curcumin , chemistry , nanofiber , chemical engineering , porosity , sericin , polymer chemistry , materials science , composite material , biomedical engineering , organic chemistry , polymer , biochemistry , medicine , engineering

A silk fibroin/poly (vinyl alcohol) porous scaffold with a water vapor transmission rate of 2125 ± 464 g/m(2)/day has been developed via thermally induced phase separation (gelation) and freeze-drying process. A hierarchical architecture of micropores and nanofibers was observed inside the scaffolds, and the related structures were analyzed. The viability and proliferation of 3T3 fibroblasts were examined, which indicated that the scaffolds exerted low cytotoxicity. After loading curcumin, the scaffolds can suppress the growth of 3T3 fibroblasts. The release behavior of curcumin from the scaffolds was investigated. At pH = 7.2, the release profiles showed no significant difference for the loading amounts of 0.5 mg and 0.25 mg per sample. Meanwhile, the cumulative amount of released drug at pH = 5.7 was significantly more than that in neutral solution due to more degradation of the scaffolds. It was suggested that the silk fibroin/poly (vinyl alcohol) blend scaffolds could be potentially used as wound dressing materials.

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