Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time | Zendy

Rong Liu | Zendy; Yida Li | Zendy; Z. Zhang | Zendy; Xin Zhang | Zendy

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Drug carriers based on highly protein-resistant materials for prolonged in vivo circulation time

Author(s) -

Rong Liu,

Yida Li,

Z. Zhang,

Xin Zhang

Publication year - 2015

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbv003

Subject(s) - ethylene glycol , drug , drug delivery , in vivo , drug carrier , pharmacology , chemistry , drug resistance , blood circulation , pharmacokinetics , blood proteins , medicine , biochemistry , microbiology and biotechnology , biology , organic chemistry , traditional medicine

Long-circulating drug carriers are highly desirable in drug delivery system. However, nonspecific protein adsorption leaves a great challenge in drug delivery of intravenous administration and significantly affects both the pharmacokinetic profiles of the carrier and drugs, resulting in negatively affect of therapeutic efficiency. Therefore, it is important to make surface modification of drug carriers by protein-resistant materials to prolong the blood circulation time and increase the targeted accumulation of therapeutic agents. In this review, we highlight the possible mechanism of protein resistance and recent progress of the alternative protein-resistant materials and their drug carriers, such as poly(ethylene glycol), oligo(ethylene glycol), zwitterionic materials, and red blood cells adhesion.

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