Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release | Zendy

Tengteng Cai | Zendy; Qi Lei | Zendy; Bin Yang | Zendy; Huizhen Jia | Zendy; Hong Cheng | Zendy; LiHan Liu | Zendy; Xuan Zeng | Zendy; Jun Feng | Zendy; RenXi Zhuo | Zendy; XianZheng Zhang | Zendy

Open Access

Utilization of H-bond interaction of nucleobase Uralic with antitumor methotrexate to design drug carrier with ultrahigh loading efficiency and pH-responsive drug release

Author(s) -

Tengteng Cai,

Qi Lei,

Bin Yang,

Huizhen Jia,

Hong Cheng,

LiHan Liu,

Xuan Zeng,

Jun Feng,

RenXi Zhuo,

XianZheng Zhang

Publication year - 2014

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbu010

Subject(s) - drug , ethylene glycol , methotrexate , anticancer drug , nanoparticle , copolymer , chemistry , combinatorial chemistry , materials science , pharmacology , nanotechnology , organic chemistry , biology , polymer , medicine

A novel Uralic (U)-rich linear-hyperbranched mono-methoxy poly (ethylene glycol)-hyperbranched polyglycerol-graft-Uralic (mPEG-HPG-g-U) nanoparticle (NP) was prepared as drug carrier for antitumor methotrexate (MTX). Due to the H-bond interaction of U with MTX and hydrophobic interaction, this NP exhibited high drug loading efficiency of up to 40%, which was significantly higher than that of traditional NPs based on U-absent copolymers (<15%). In addition, MTX-loaded mPEG-HPG-g-U NPs also demonstrated an acidity-accelerated drug release behavior.

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