Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing | Zendy

Yu-Ting Chen | Zendy; Jinhong Cai | Zendy; Dachang Liu | Zendy; Shuhan Liu | Zendy; Doudou Lei | Zendy; Li Zheng | Zendy; Qingjun Wei | Zendy; Ming Gao | Zendy

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Zinc-based metal organic framework with antibacterial and anti-inflammatory properties for promoting wound healing

Author(s) -

Yu-Ting Chen,

Jinhong Cai,

Dachang Liu,

Shuhan Liu,

Doudou Lei,

Li Zheng,

Qingjun Wei,

Ming Gao

Publication year - 2022

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbac019

Subject(s) - wound healing , zinc , chemistry , antibacterial activity , push pull , medicine , engineering , surgery , bacteria , organic chemistry , biology , genetics , electrical engineering

The synergistic effect of antibacterial and anti-inflammatory is needed to overcome the problem of wound healing difficulties. Based on the favorable antibacterial and anti-inflammatory effect of zinc ions (Zn2+) and the physicochemical properties of metal organic frameworks (MOFs), we prepared nanosized zinc-based MOF: Zn-BTC with the ability to slowly release Zn2+. In cellular levels, Zn-BTC possessed lower toxicity to fibroblasts and enhanced capacity of cell proliferation and migration. It also had good bactericidal effect on multiple drug-resistant bacteria by reducing 41.4% MRSA and 47.2% Escherichia coli. In addition, Zn-BTC also displayed the ability of lowering the expression of antioxidant genes: superoxide dismutase 1, superoxide dismutase 2 and interleukin 6, and enhancing the expression of wound healing genes: transforming growth factors-β and type I collagen. Finally, it also demonstrated that Zn-BTC could effectively improve the skin wound healing of SD rats and had no toxicity on major organs. The favorable biocompatibility, antibacterial and anti-inflammatory properties of Zn-BTC gave a new insight of designing novel MOFs for promoting skin wound healing.

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