Open AccessNitric oxide-releasing polyurethane/S-nitrosated keratin mats for accelerating wound healing
Author(s) -
Jie Dou,
Rong Yang,
Xingxing Jin,
Pengfei Li,
Xiao Han,
Lijuan Wang,
Bo Chi,
Jian Shen,
Jiang Yuan
Publication year - 2022
Publication title -
regenerative biomaterials
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.166
H-Index - 25
ISSN - 2056-3426
DOI - 10.1093/rb/rbac006
Subject(s) - wound healing , angiogenesis , chemistry , polyurethane , in vivo , biocomposite , fibroblast , nitric oxide , cell migration , keratin , biomedical engineering , cell , biochemistry , surgery , pathology , in vitro , medicine , cancer research , materials science , biology , composite material , microbiology and biotechnology , organic chemistry , composite number
Nitric oxide (NO) plays an important role in wound healing, due to its ability to contract wound surfaces, dilate blood vessels, participate in inflammation as well as promote collagen synthesis, angiogenesis, and fibroblast proliferation. Herein, keratin was first nitrosated to afford S-nitrosated keratin (KSNO). As a NO donor, KSNO was then co-electrospun with polyurethane (PU). These as-spun PU/KSNO biocomposite mats could release NO sustainably for 72 h, matching the renewal time of the wound dressing. Moreover, these mats exhibited excellent cytocompatibility with good cell adhesion and cell migration. Further, the biocomposite mats exhibited antibacterial properties without inducing severe inflammatory responses. The wound repair in vivo demonstrated that these mats accelerated wound healing by promoting tissue formation, collagen deposition, cell migration, reepithelialization, and angiogenesis. Overall, PU/KSNO mats may be promising candidates for wound dressing.
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