Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging | Zendy

Li Yang | Zendy; Shengxiang Fu | Zendy; Li Liu | Zendy; Zhongyuan Cai | Zendy; Chunchao Xia | Zendy; Bin Song | Zendy; Qiyong Gong | Zendy; Zhiyun Lu | Zendy; Hua Ai | Zendy

Open Access

Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging

Author(s) -

Li Yang,

Shengxiang Fu,

Li Liu,

Zhongyuan Cai,

Chunchao Xia,

Bin Song,

Qiyong Gong,

Zhiyun Lu,

Hua Ai

Publication year - 2021

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbab023

Subject(s) - tetraphenylethylene , alkyl , materials science , nanocomposite , fluorescence , conjugated system , amphiphile , photochemistry , nile red , chemistry , copolymer , nanotechnology , polymer , organic chemistry , optics , physics , aggregation induced emission

Magnetic resonance (MR)/optical dual-mode imaging with high sensitivity and high tissue resolution have attracted many attentions in biomedical applications. To avert aggregation-caused quenching of conventional fluorescence chromophores, an aggregation-induced emission molecule tetraphenylethylene (TPE)-conjugated amphiphilic polyethylenimine (PEI) covered superparamagnetic iron oxide (Alkyl-PEI-LAC-TPE/SPIO nanocomposites) was prepared as an MR/optical dual-mode probe. Alkyl-PEI-LAC-TPE/SPIO nanocomposites exhibited good fluorescence property and presented higher T 2 relaxivity (352 Fe mM −1 s −1 ) than a commercial contrast agent Feridex (120 Fe mM −1 s −1 ) at 1.5 T. The alkylation degree of Alkyl-PEI-LAC-TPE effects the restriction of intramolecular rotation process of TPE. Reducing alkane chain grafting ratio aggravated the stack of TPE, increasing the fluorescence lifetime of Alkyl-PEI-LAC-TPE/SPIO nanocomposites. Alkyl-PEI-LAC-TPE/SPIO nanocomposites can effectively labelled HeLa cells and resulted in high fluorescence intensity and excellent MR imaging sensitivity. As an MR/optical imaging probe, Alkyl-PEI-LAC-TPE/SPIO nanocomposites may be used in biomedical imaging for certain applications.

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