Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration | Zendy

Kun Liu | Zendy; Chun-Xiu Meng | Zendy; Zhao-Yong Lv | Zendy; Yujue Zhang | Zendy; Jun Li | Zendy; Keyi Li | Zendy; Fengzhen Liu | Zendy; Bin Zhang | Zendy; Fuzhai Cui | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Enhancement of BMP-2 and VEGF carried by mineralized collagen for mandibular bone regeneration

Author(s) -

Kun Liu,

Chun-Xiu Meng,

Zhao-Yong Lv,

Yujue Zhang,

Jun Li,

Keyi Li,

Fengzhen Liu,

Bin Zhang,

Fuzhai Cui

Publication year - 2020

Publication title -

regenerative biomaterials

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.166

H-Index - 25

ISSN - 2056-3426

DOI - 10.1093/rb/rbaa022

Subject(s) - intramembranous ossification , angiogenesis , vascular endothelial growth factor , chemistry , regeneration (biology) , ossification , bone morphogenetic protein 2 , craniofacial , anatomy , pathology , microbiology and biotechnology , vegf receptors , medicine , biology , biochemistry , psychiatry , in vitro

Repairing damage in the craniofacial skeleton is challenging. Craniofacial bones require intramembranous ossification to generate tissue-engineered bone grafts via angiogenesis and osteogenesis. Here, we designed a mineralized collagen delivery system for BMP-2 and vascular endothelial growth factor (VEGF) for implantation into animal models of mandibular defects. BMP-2/VEGF were mixed with mineralized collagen which was implanted into the rabbit mandibular. Animals were divided into (i) controls with no growth factors; (ii) BMP-2 alone; or (iii) BMP-2 and VEGF combined. CT and hisomputed tomography and histological staining were performed to assess bone repair. New bone formation was higher in BMP-2 and BMP-2-VEGF groups in which angiogenesis and osteogenesis were enhanced. This highlights the use of mineralized collagen with BMP-2/VEGF as an effective alternative for bone regeneration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research