Predicting relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis: a Systematic review and meta-analysis | Zendy

Catherine King | Zendy; Katie L. Druce | Zendy; Peter Nightingale | Zendy; Ellen Kay | Zendy; Neil Basu | Zendy; Alan D. Salama | Zendy; Lorraine Harper | Zendy

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Predicting relapse in anti-neutrophil cytoplasmic antibody-associated vasculitis: a Systematic review and meta-analysis

Author(s) -

Catherine King,

Katie L. Druce,

Peter Nightingale,

Ellen Kay,

Neil Basu,

Alan D. Salama,

Lorraine Harper

Publication year - 2021

Publication title -

rheumatology advances in practice

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.539

H-Index - 4

ISSN - 2514-1775

DOI - 10.1093/rap/rkab018

Subject(s) - medicine , creatinine , hazard ratio , meta analysis , vasculitis , anca associated vasculitis , multivariate analysis , confidence interval , disease

Relapses affect 30-50% of patients with anti-neutrophil cytoplasm antibody (ANCA) associated vasculitis (AAV) over 5 years. Whilst relapses are associated with accumulating disease and treatment related damage, prolonged maintenance therapy to reduce the risk of relapse is also coupled with toxicity. Whilst there have been studies looking at predictors of relapse in AAV, this research has yet to translate clinically into guidance on tailored therapy. The aim of this systematic review was to meta-analyse existing risk factors from the literature and then produce a model to help stratification of immunosuppression therapy for patients at risk of disease relapse.

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