Structural Brain Alterations Before and After Total Knee Arthroplasty: A Longitudinal Assessment | Zendy

Gwyn N. Lewis | Zendy; Rosalind S. Parker | Zendy; Sheena Sharma | Zendy; David A. Rice | Zendy; Peter J. McNair | Zendy

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Structural Brain Alterations Before and After Total Knee Arthroplasty: A Longitudinal Assessment

Author(s) -

Gwyn N. Lewis,

Rosalind S. Parker,

Sheena Sharma,

David A. Rice,

Peter J. McNair

Publication year - 2018

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pny108

Subject(s) - medicine , fractional anisotropy , nociception , magnetic resonance imaging , white matter , voxel based morphometry , osteoarthritis , atrophy , brain morphometry , chronic pain , grey matter , anesthesia , physical medicine and rehabilitation , physical therapy , pathology , radiology , receptor , alternative medicine

Many studies have provided evidence of altered brain structure in chronic pain conditions, as well as further adaptations following treatment that are coincident with changes in pain. Less is known regarding how these structural brain adaptations relate to assessments of nociceptive processing. The current study aimed to investigate brain structure in people with knee osteoarthritis (OA) before and after total knee arthroplasty (TKA) and to investigate the relationships between these findings and quantitative sensory testing (QST) of the nociceptive system.

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