Open AccessBuprenorphine Maintenance Subjects Are Hyperalgesic and Have No Antinociceptive Response to a Very High Morphine Dose
Author(s) -
Peter Athanasos,
Walter Ling,
Felix Bochner,
Jason M. White,
Andrew A. Somogyi
Publication year - 2018
Publication title -
pain medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.893
H-Index - 97
eISSN - 1526-4637
pISSN - 1526-2375
DOI - 10.1093/pm/pny025
Subject(s) - buprenorphine , morphine , medicine , nociception , anesthesia , opioid , pharmacology , receptor
Acute pain management in opioid-dependent persons is complicated because of tolerance and opioid-induced hyperalgesia. Very high doses of morphine are ineffective in overcoming opioid-induced hyperalgesia and providing antinociception to methadone-maintained patients in an experimental setting. Whether the same occurs in buprenorphine-maintained subjects is unknown.
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