Assessment of Neurological Toxicity of Hydroxyethyl Starch 130/0.4 Injected in the Intrathecal Space in Rats | Zendy

O. Vassal | Zendy; Peggy del Carmine | Zendy; F-P Desgranges | Zendy; Lionel Bouvet | Zendy; Marc Lilot | Zendy; Nicolas Gadot | Zendy; Quadiri Timour-Chah | Zendy; D. Chassard | Zendy

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Assessment of Neurological Toxicity of Hydroxyethyl Starch 130/0.4 Injected in the Intrathecal Space in Rats

Author(s) -

O. Vassal,

Peggy del Carmine,

F-P Desgranges,

Lionel Bouvet,

Marc Lilot,

Nicolas Gadot,

Quadiri Timour-Chah,

D. Chassard

Publication year - 2018

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pny005

Subject(s) - medicine , toxicity , hydroxyethyl starch , saline , anesthesia , intrathecal , spinal cord , epidural space , psychiatry

Epidural blood patch is the procedure of choice to relieve postdural puncture headache. Hydroxyethyl-starch (HES) has been proposed as a patch in some circumstances such as in the case of hematological disease due to the theoretical risk of neoplastic seeding to the central nervous system. Acute neurological HES toxicity has been excluded by a previous animal study, but the long-term neurological toxicity has not been evaluated.

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