Pulsed Radiofrequency Attenuates Complete Freund’s Adjuvant–Induced Epigenetic Suppression of Potassium Chloride Cotransporter 2 Expression | Zendy

Chia-Kai Liu | Zendy; Wen-Tzu Liao | Zendy; Yu-Chi Chu | Zendy; Chien-Hui Yang | Zendy; KuanHung Chen | Zendy; Chih-Hsien Wu | Zendy; ChungRen Lin | Zendy

Open Access

Pulsed Radiofrequency Attenuates Complete Freund’s Adjuvant–Induced Epigenetic Suppression of Potassium Chloride Cotransporter 2 Expression

Author(s) -

Chia-Kai Liu,

Wen-Tzu Liao,

Yu-Chi Chu,

Chien-Hui Yang,

KuanHung Chen,

Chih-Hsien Wu,

ChungRen Lin

Publication year - 2016

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pnw243

Subject(s) - epigenetics , adjuvant , medicine , cotransporter , chloride , potassium , cancer research , pharmacology , chemistry , biochemistry , gene , sodium , organic chemistry

Pulsed radiofrequency (PRF) treatment offers pain relief for patients suffering from chronic pain who do not respond well to conventional treatments. We tested whether PRF treatment attenuated complete Freund's adjuvant (CFA)-induced inflammatory pain. Epigenetic modification of potassium-chloride cotransporter 2 (KCC2) gene expression was examined to elucidate the potential contributing mechanism.

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