Comparison of the Effects of Intermittent Boluses to Simple Continuous Infusion on Patients’ Global Perceived Effect in Intrathecal Therapy for Pain: A Randomized Double-Blind Crossover Study | Zendy

Sam Eldabe | Zendy; Rui Duarte | Zendy; Grace Madzinga | Zendy; Alan M. Batterham | Zendy; Morag Brookes | Zendy; Ashish Gulve | Zendy; Christophe Perruchoud | Zendy; Jon H. Raphael | Zendy; David Lorenzana | Zendy; Eric Buchser | Zendy

Open Access

Comparison of the Effects of Intermittent Boluses to Simple Continuous Infusion on Patients’ Global Perceived Effect in Intrathecal Therapy for Pain: A Randomized Double-Blind Crossover Study

Author(s) -

Sam Eldabe,

Rui Duarte,

Grace Madzinga,

Alan M. Batterham,

Morag Brookes,

Ashish Gulve,

Christophe Perruchoud,

Jon H. Raphael,

David Lorenzana,

Eric Buchser

Publication year - 2016

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pnw229

Subject(s) - medicine , bolus (digestion) , anesthesia , crossover study , adverse effect , confidence interval , randomized controlled trial , dose , placebo , surgery , alternative medicine , pathology

Intrathecal drug delivery (ITDD) is commonly used for intractable pain management. A paucity of good-quality studies in chronic noncancer patients and concerns over increased dosages have focused interest on different modes of administration. The aim of this international multicenter randomized double-blind crossover trial was to compare the efficacy of the same daily dose of drugs administered by intermittent boluses vs simple continuous infusion.

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