Characterization of Macrophage/Microglial Activation and Effect of Photobiomodulation in the Spared Nerve Injury Model of Neuropathic Pain | Zendy

Ann K. Ketz | Zendy; Kimberly R. Byrnes | Zendy; Neil E. Grunberg | Zendy; Christine E. Kasper | Zendy; Lisa A. Osborne | Zendy; Brian A. Pryor | Zendy; Nicholas L. Tosini | Zendy; Xingjia Wu | Zendy; Juanita J. Anders | Zendy

Open Access

Characterization of Macrophage/Microglial Activation and Effect of Photobiomodulation in the Spared Nerve Injury Model of Neuropathic Pain

Author(s) -

Ann K. Ketz,

Kimberly R. Byrnes,

Neil E. Grunberg,

Christine E. Kasper,

Lisa A. Osborne,

Brian A. Pryor,

Nicholas L. Tosini,

Xingjia Wu,

Juanita J. Anders

Publication year - 2016

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pnw144

Subject(s) - neuropathic pain , medicine , nerve injury , microglia , spinal cord injury , peripheral nerve injury , spinal cord , sni , anesthesia , sciatic nerve , inflammation , chemistry , biochemistry , psychiatry , hydrolysis , acid hydrolysis

Neuropathic pain is common and debilitating with limited effective treatments. Macrophage/microglial activation along ascending somatosensory pathways following peripheral nerve injury facilitates neuropathic pain. However, polarization of macrophages/microglia in neuropathic pain is not well understood. Photobiomodulation treatment has been used to decrease neuropathic pain, has anti-inflammatory effects in spinal injury and wound healing models, and modulates microglial polarization in vitro. Our aim was to characterize macrophage/microglia response after peripheral nerve injury and modulate the response with photobiomodulation.

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