Effects of Low-DoseEscherichia coliLipopolysaccharide-Induced Endotoxemia on Morphine Pharmacokinetics in an Animal Model | Zendy

Danuta Szkutnik-Fiedler | Zendy; Hanna Billert | Zendy; Tomasz Grabowski | Zendy; Justyna Lisiecka | Zendy; Michał Michalak | Zendy; Hanna Urjasz | Zendy; Edmund Grześkowiak | Zendy

Open Access

Effects of Low-DoseEscherichia coliLipopolysaccharide-Induced Endotoxemia on Morphine Pharmacokinetics in an Animal Model

Author(s) -

Danuta Szkutnik-Fiedler,

Hanna Billert,

Tomasz Grabowski,

Justyna Lisiecka,

Michał Michalak,

Hanna Urjasz,

Edmund Grześkowiak

Publication year - 2015

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pnv030

Subject(s) - pharmacokinetics , morphine , medicine , volume of distribution , pharmacology , elimination rate constant , bioavailability , dosing , lipopolysaccharide , analgesic , anesthesia , distribution (mathematics) , mathematical analysis , mathematics

Systemic inflammation may change the bioavailability and pharmacokinetics of opioids. However, there are insufficient data on morphine pharmacokinetics in mild inflammatory conditions. This study aimed to determine the pharmacokinetics of morphine during low-dose endotoxemia in rabbits.

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