Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines? | Zendy

Haewon Lee | Zendy; Jennifer A. Punt | Zendy; D. Craig Miller | Zendy; Ameet Nagpal | Zendy; Clark C Smith | Zendy; Yusef Sayeed | Zendy; Jaymin Patel | Zendy; Milan P. Stojanovic | Zendy; Adrian Popescu | Zendy; Zachary L. McCormick | Zendy

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Do Corticosteroid Injections for the Treatment of Pain Influence the Efficacy of mRNA COVID-19 Vaccines?

Author(s) -

Haewon Lee,

Jennifer A. Punt,

D. Craig Miller,

Ameet Nagpal,

Clark C Smith,

Yusef Sayeed,

Jaymin Patel,

Milan P. Stojanovic,

Adrian Popescu,

Zachary L. McCormick

Publication year - 2021

Publication title -

pain medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.893

H-Index - 97

eISSN - 1526-4637

pISSN - 1526-2375

DOI - 10.1093/pm/pnab063

Subject(s) - medicine , corticosteroid , covid-19 , messenger rna , anesthesia , immunology , disease , biology , biochemistry , infectious disease (medical specialty) , gene

MYTH: Corticosteroid injection for the treatment of pain and inflammation is known to decrease the efficacy of the messenger ribonucleic acid (mRNA) vaccines for coronavirus disease 2019 (COVID-19). FACT: There is currently no direct evidence to suggest that a corticosteroid injection before or after the administration of an mRNA COVID-19 vaccine decreases the efficacy of the vaccine.However, based on the known timeline of hypothalamic-pituitary-adrenal (HPA) axis suppression following epidural and intraarticular corticosteroid injections, and the timeline of the reported peak efficacy of the Pfizer-BioNTech and Moderna vaccines, physicians should consider timing an elective corticosteroid injection such that it is administered no less than 2 weeks prior to a COVID-19 mRNA vaccine dose and no less than 1 week following a COVID-19 mRNA vaccine dose, whenever possible.

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