PKS Activities and Biosynthesis of Cannabinoids and Flavonoids in Cannabis sativa L. Plants | Zendy

Isvett Josefina FloresSanchez | Zendy; Robert Verpoorte | Zendy

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PKS Activities and Biosynthesis of Cannabinoids and Flavonoids in Cannabis sativa L. Plants

Author(s) -

Isvett Josefina FloresSanchez,

Robert Verpoorte

Publication year - 2008

Publication title -

plant and cell physiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.975

H-Index - 152

eISSN - 1471-9053

pISSN - 0032-0781

DOI - 10.1093/pcp/pcn150

Subject(s) - chalcone synthase , biosynthesis , atp synthase , polyketide synthase , biochemistry , cannabinoid , cannabis sativa , enzyme , biology , trichome , chemistry , botany , polyketide , receptor

Polyketide synthase (PKS) enzymatic activities were analyzed in crude protein extracts from cannabis plant tissues. Chalcone synthase (CHS, EC 2.3.1.74), stilbene synthase (STS, EC 2.3.1.95), phlorisovalerophenone synthase (VPS, EC 2.3.1.156), isobutyrophenone synthase (BUS) and olivetol synthase activities were detected during the development and growth of glandular trichomes on bracts. Cannabinoid biosynthesis and accumulation take place in these glandular trichomes. In the biosynthesis of the first precursor of cannabinoids, olivetolic acid, a PKS could be involved; however, no activity for an olivetolic acid-forming PKS was detected. Content analyses of cannabinoids and flavonoids, two secondary metabolites present in this plant, from plant tissues revealed differences in their distribution, suggesting a diverse regulatory control for these biosynthetic fluxes in the plant.

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