Guidelines for surfactant replacement therapy in neonates | Zendy

Nalini Singhal | Zendy; Vibhuti Shah | Zendy

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Guidelines for surfactant replacement therapy in neonates

Author(s) -

Nalini Singhal,

Vibhuti Shah

Publication year - 2021

Publication title -

paediatrics and child health

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.55

H-Index - 43

eISSN - 1918-1485

pISSN - 1205-7088

DOI - 10.1093/pch/pxaa116

Subject(s) - medicine , meconium aspiration syndrome , respiratory distress , surfactant therapy , pulmonary surfactant , intensive care medicine , neonatal respiratory distress syndrome , meconium , airway , rescue therapy , continuous positive airway pressure , anesthesia , pediatrics , surgery , pregnancy , gestational age , fetus , genetics , physics , obstructive sleep apnea , biology , thermodynamics

Surfactant replacement therapy (SRT) plays a pivotal role in the management of neonates with respiratory distress syndrome (RDS) because it improves survival and reduces respiratory morbidities. With the increasing use of noninvasive ventilation as the primary mode of respiratory support for preterm infants at delivery, prophylactic surfactant is no longer beneficial. For infants with worsening RDS, early rescue surfactant should be provided. While the strategy to intubate, give surfactant, and extubate (INSURE) has been widely accepted in clinical practice, newer methods of noninvasive surfactant administration, using thin catheter, laryngeal mask airway, or nebulization, are being adopted or investigated. Use of SRT as an adjunct for conditions other than RDS, such as meconium aspiration syndrome, may be effective based on limited evidence.

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