Blurring the Lines of Design: Prospective Observational Cohorts and Pragmatic Clinical Trials Characterizing Treatment Effects in Routine Cancer Care | Zendy

Donna R. Rivera | Zendy; Erin Larkins | Zendy; Paul G. Kluetz | Zendy

Open Access

Blurring the Lines of Design: Prospective Observational Cohorts and Pragmatic Clinical Trials Characterizing Treatment Effects in Routine Cancer Care

Author(s) -

Donna R. Rivera,

Erin Larkins,

Paul G. Kluetz

Publication year - 2022

Publication title -

the oncologist

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.176

H-Index - 164

eISSN - 1549-490X

pISSN - 1083-7159

DOI - 10.1093/oncolo/oyab071

Subject(s) - medicine , observational study , clinical trial , real world data , clinical practice , clinical study design , intensive care medicine , medical physics , health care , research design , family medicine , data science , computer science , social science , sociology , economics , economic growth

Real-world data is emerging as a source of data to evaluate drug effects that may provide unique benefits given the highly selected enrollment and participation of adult patients in clinical trials. This commentary considers the potential utility of real-world data in light of the recently reported results of the FLOWER study, which explore the safety and efficacy of osimertinib using a prospective single-arm design with real-world data sourced from clinical practice.

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