Chronic genotype 1 hepatitis E infection from immunosuppression for ileo-colonic Crohn’s disease | Zendy

Anne Robins | Zendy; David J. Bowden | Zendy; William Gelson | Zendy

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Chronic genotype 1 hepatitis E infection from immunosuppression for ileo-colonic Crohn’s disease

Author(s) -

Anne Robins,

David J. Bowden,

William Gelson

Publication year - 2018

Publication title -

oxford medical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.169

H-Index - 9

ISSN - 2053-8855

DOI - 10.1093/omcr/omy059

Subject(s) - medicine , immunosuppression , context (archaeology) , primary sclerosing cholangitis , inflammatory bowel disease , prednisolone , gastroenterology , exacerbation , crohn's disease , ribavirin , hepatitis c , azathioprine , immunology , disease , hepatitis c virus , virus , paleontology , biology

We report a case of a 33-year-old man with a background of longstanding ileo-colonic Crohn's disease and primary sclerosing cholangitis. Following a trip to India he developed diarrhoea which was treated as an exacerbation of Crohn's disease. Liver tests became chronically deranged after increasing immunosuppression, which comprised mercaptopurine, adalimumab and prednisolone. Chronic genotype 1 hepatitis E was diagnosed and successfully treated with reduction of immunosuppression followed by a 24-week course of ribavirin. We believe that this is the first reported case of chronic hepatitis E in genotype 1. Deranged liver tests should prompt testing for hepatitis E infection in the context of immunosuppression for inflammatory bowel disease.

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