Single dose of propofol causing propofol infusion syndrome in a newborn | Zendy

Carolina Michel-Macías | Zendy; Deneb Algedi Morales-Barquet | Zendy; A M Reyes-Palomino | Zendy; J A Machuca-Vaca | Zendy; Alejandra Orozco-Guillén | Zendy

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Single dose of propofol causing propofol infusion syndrome in a newborn

Author(s) -

Carolina Michel-Macías,

Deneb Algedi Morales-Barquet,

A M Reyes-Palomino,

J A Machuca-Vaca,

Alejandra Orozco-Guillén

Publication year - 2018

Publication title -

oxford medical case reports

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.169

H-Index - 9

ISSN - 2053-8855

DOI - 10.1093/omcr/omy023

Subject(s) - medicine , propofol , rhabdomyolysis , metabolic acidosis , anesthesia , bolus (digestion) , acidosis , surgery

Propofol infusion syndrome (PRIS) is a rare syndrome originally described in critically ill children undergoing long-term (> 48 h) propofol infusion at high doses (> 4 mg/kg/h). Severe metabolic acidosis, rhabdomyolysis, renal failure and fatal cardiac failure are the features. Herein, we present a case of a newborn who developed PRIS after a single bolus dose of propofol at 3.2 mg/kg/do, developing rhabdomyolysis and severe metabolic acidosis, with a successful outcome after medical therapy.

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