Polydrug abuse associated with nitrous oxide causes death

The case report by Hirvioja et al. raises some interesting points [1]. Unfortunately, the title is somewhat misleading because it suggests that it was nitrous oxide alone that caused the death and ignores the likelihood, from the data presented, that the death was probably due to the other substances found in the patientu0027s blood as well as the nitrous oxide [1]. As far as I am aware, there is no case in the literature where nitrous oxide alone has caused sudden death during misuse, except when the subject has been asphyxiated because of oxygen lack [2].