Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected &lt;20 Copies/mL | Zendy

Shelli Farhadian | Zendy; Hetal Mistry | Zendy; Tobias Kirchwey | Zendy; Jennifer Chiarella | Zendy; Rachela Calvi | Zendy; Michelle Chintanaphol | Zendy; Payal Patel | Zendy; Marie L. Landry | Zendy; Kevin Robertson | Zendy; Serena Spudich | Zendy

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Markers of CNS Injury in Adults Living With HIV With CSF HIV Not Detected vs Detected <20 Copies/mL

Author(s) -

Shelli Farhadian,

Hetal Mistry,

Tobias Kirchwey,

Jennifer Chiarella,

Rachela Calvi,

Michelle Chintanaphol,

Payal Patel,

Marie L. Landry,

Kevin Robertson,

Serena Spudich

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz528

Subject(s) - cerebrospinal fluid , medicine , rna , central nervous system , human immunodeficiency virus (hiv) , immune system , antiretroviral therapy , immunology , viral load , pathology , biology , gene , biochemistry

The presence of quantifiable HIV RNA in cerebrospinal fluid (CSF) during antiretroviral therapy (ART) can associate with central nervous system (CNS) pathology, but the significance of RNA detected below the limit of quantification (LOQ) on a standard assay during ART remains unknown. We compared CNS parameters between individuals with CSF RNA detected below the LOQ (20 copies/mL) with those with HIV RNA not detected. Detection of CSF HIV RNA associated with decreased blood-brain barrier integrity and with decreased executive function, but not with CNS immune activation or poorer performance in overall neuropsychological testing.

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