Persistent Systemic Microbial Translocation, Inflammation, and Intestinal Damage During Clostridioides difficile Infection | Zendy

Alessandra Oliva | Zendy; Lucia Aversano | Zendy; Massimiliano De Angelis | Zendy; Maria Teresa Mascellino | Zendy; Maria Claudia Miele | Zendy; Sergio Morelli | Zendy; Riccardo Battaglia | Zendy; Jessica Iera | Zendy; Giovanni Bruno | Zendy; Enrico Corazziari | Zendy; Maria Rosa Ciardi | Zendy; Mario Venditti | Zendy; Claudio Maria Mastroianni | Zendy; Vincenzo Vullo | Zendy

Open Access

Persistent Systemic Microbial Translocation, Inflammation, and Intestinal Damage During Clostridioides difficile Infection

Author(s) -

Alessandra Oliva,

Lucia Aversano,

Massimiliano De Angelis,

Maria Teresa Mascellino,

Maria Claudia Miele,

Sergio Morelli,

Riccardo Battaglia,

Jessica Iera,

Giovanni Bruno,

Enrico Corazziari,

Maria Rosa Ciardi,

Mario Venditti,

Claudio Maria Mastroianni,

Vincenzo Vullo

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz507

Subject(s) - medicine , gastroenterology , inflammation , chromosomal translocation , clostridioides , bacterial translocation , population , systemic inflammation , immunology , microbiology and biotechnology , biology , biochemistry , environmental health , gene

CDI is associated with high levels of microbial translocation, inflammation, and intestinal damage, which are still present at clinical resolution of CDI. The role of residual mucosal perturbation and persistence of intestinal cell damage in the development of n-BSI following CDI, as well as the possible effect of FMT in the restoration of mucosal integrity, should be further investigated.

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