Detection and Characterization of Influenza B Virus with Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient | Zendy

Rosy Priya Kodiyanplakkal | Zendy; Jennifer Laplante | Zendy; Lars F. Westblade | Zendy; Koen van Besien | Zendy; Mirella Salvatore | Zendy; Kirsten St. George | Zendy

Open Access

Detection and Characterization of Influenza B Virus with Reduced Neuraminidase Susceptibility in a Stem Cell Transplant Recipient

Author(s) -

Rosy Priya Kodiyanplakkal,

Jennifer Laplante,

Lars F. Westblade,

Koen van Besien,

Mirella Salvatore,

Kirsten St. George

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz493

Subject(s) - neuraminidase , medicine , influenzavirus b , virology , neuraminidase inhibitor , oseltamivir , virus , zanamivir , stem cell , influenza a virus , immunology , orthomyxoviridae , covid-19 , biology , genetics , infectious disease (medical specialty) , disease

Antiviral-resistant influenza viruses in the clinical environment, especially type B, are rarely reported. A stem cell transplant recipient remained influenza B positive for two months, despite repeated antiviral treatments. Laboratory tests demonstrated the evolution and persistence of neuraminidase inhibitor-resistant influenza B virus with a substitution at codon 119.

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