Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult | Zendy

Kevin S Ikuta | Zendy; Pavitra Roychoudhury | Zendy; Hong Xie | Zendy; Christopher L. McClurkan | Zendy; Magdalena Walkiewicz | Zendy; Negar Makhsous | Zendy; MeeiLi Huang | Zendy; Yodit N. Beru | Zendy; Mariam Alam | Zendy; Amanda Shepherd | Zendy; Eric Daniel LaMotte | Zendy; Kevin Patel | Zendy; Amy Morris | Zendy; Başak Ҫoruh | Zendy; Lei Yu | Zendy; Renuka Bhattacharya | Zendy; Rex Cheng | Zendy; Roland B. Walter | Zendy; Ajit P. Limaye | Zendy; Christina M. Lockwood | Zendy; Steven M. Holland | Zendy; Robert M. Rakita | Zendy; David M. Koelle | Zendy; Alexander L. Greninger | Zendy

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Trillions and Trillions: Herpes Simplex Virus–1 Hepatitis in an Immunocompetent Adult

Author(s) -

Kevin S Ikuta,

Pavitra Roychoudhury,

Hong Xie,

Christopher L. McClurkan,

Magdalena Walkiewicz,

Negar Makhsous,

MeeiLi Huang,

Yodit N. Beru,

Mariam Alam,

Amanda Shepherd,

Eric Daniel LaMotte,

Kevin Patel,

Amy Morris,

Başak Ҫoruh,

Lei Yu,

Renuka Bhattacharya,

Rex Cheng,

Roland B. Walter,

Ajit P. Limaye,

Christina M. Lockwood,

Steven M. Holland,

Robert M. Rakita,

David M. Koelle,

Alexander L. Greninger

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz465

Subject(s) - medicine , viremia , herpes simplex virus , virology , hsl and hsv , virus , immunology

We describe a case of acute liver failure and myopericarditis due to herpes simplex virus-1 (HSV-1) in an immunocompetent adult. We estimate that, at the height of viremia, the patient contained a quantity of HSV-1 virions approaching that of human cells. The patient recovered with acyclovir that was dose-adjusted for neurotoxicity and developed a vigorous anti-HSV-1 T-cell response.

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