Blood Culture–Negative Cardiovascular Infection in a Patient With Multiple Sclerosis | Zendy

Cléa Melenotte | Zendy; Ahmed Loukil | Zendy; Audrey Rico | Zendy; Hubert Lépidi | Zendy; Didier Raoult | Zendy

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Blood Culture–Negative Cardiovascular Infection in a Patient With Multiple Sclerosis

Author(s) -

Cléa Melenotte,

Ahmed Loukil,

Audrey Rico,

Hubert Lépidi,

Didier Raoult

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz429

Subject(s) - medicine , endocarditis , immunosuppression , polymerase chain reaction , serology , blood culture , biopsy , infective endocarditis , in situ hybridization , pathology , immunology , antibody , antibiotics , microbiology and biotechnology , gene , biochemistry , chemistry , gene expression , biology

A patient with multiple sclerosis presented with seronegative C. burnetii endocarditis diagnosed using C. burnetii–specific polymerase chain reaction and fluorescence in situ hybridization on cardiovascular biopsy. This case supports the necessity of a systematic polymerase chain reaction testing of removed cardiac valves because blood culture–negative endocarditis can be pauci-symptomatic, and serological tests can be negative in cases of immunosuppression.

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