Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy | Zendy

Alexandra AudemardVerger | Zendy; Jacques Gasnault | Zendy; Maxime Faisant | Zendy; Marie-Catherine Besse | Zendy; Nicolas Martin Silva | Zendy; Mado Berra | Zendy; Luc Fournier | Zendy; Jonathan Boutémy | Zendy; G. Maigné | Zendy; Hubert de Boysson | Zendy; Alexis Ruet | Zendy; Astrid Vabret | Zendy; Françoise Chapon | Zendy; Guillaume MartinBlondel | Zendy; Achille Aouba | Zendy

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Sustained Response and Rationale of Programmed Cell Death-1-Targeting for Progressive Multifocal Leukoencephalopathy

Author(s) -

Alexandra AudemardVerger,

Jacques Gasnault,

Maxime Faisant,

Marie-Catherine Besse,

Nicolas Martin Silva,

Mado Berra,

Luc Fournier,

Jonathan Boutémy,

G. Maigné,

Hubert de Boysson,

Alexis Ruet,

Astrid Vabret,

Françoise Chapon,

Guillaume MartinBlondel,

Achille Aouba

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz374

Subject(s) - progressive multifocal leukoencephalopathy , medicine , leukoencephalopathy , brain biopsy , pathology , nivolumab , immune system , programmed cell death 1 , biopsy , immunology , virus , immunotherapy , pd l1 , disease

In this study, we report a complete (clinical, radiological, and virological) sustained (1 year) response after nivolumab salvage therapy in a progressive multifocal leukoencephalopathy patient. Analyses of the cells infiltrate in a pretreatment brain biopsy suggest that parenchymal programmed cell death-L1+ macrophages could be the T-cells partnership in immune exhaustion and virus escape.

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