2209. Charlson Comorbidity Index Scores and In-hospital Prognosis in Severe Acute Respiratory Infections Patients

Background Respiratory infections are one of the leading causes of mortality, and comorbid conditions play a significant role in the severity and fatality of these infections. The Charlson Comorbidity index (CCI) is the most used comorbidity index, presenting a few updated versions since its establishment. In the present study, we evaluated the CCI score and possible predictors of mortality in hospitalized patients with Severe Acute Respiratory Infection (SARI), aiming to test whether the CCI is a valid in-hospital prognostic indicator. Methods Patients older than 14 years, hospitalized from 2010 to 2016 due to SARI by viral infection, and who were submitted to respiratory virus testing were included. We assessed comorbidity retrospectively through chart review, and calculated 4 variants of the CCI. Results Of the 291 patients assessed, 72.8% (n = 212) presented comorbidities and 24% died (n = 70). The most recurrent comorbidities were Chronic Pulmonary Disease (n = 76/212, 36%) and HIV (n = 50/212, 23.6%). Respiratory virus testing was positive in 38.1% of patients (n = 111), Influenza and Rhinoviruses being the most frequent. The 1994 Age-adjusted CCI predicted in-hospital mortality in SARI patients (P = 0.04), and HIV was independently associated with in-hospital mortality (P = 0.032). Conclusion The comorbidity scores used to assess mortality risk in hospitalized patients with SARI displayed poor results, but HIV infection was considered a marker of severity. However, other factors should be considered in order to compose a scoring system that allows us to specifically assess the risk of mortality in patients with SARI. Disclosures All authors: No reported disclosures.