Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection | Zendy

Veronica Bordoni | Zendy; Eleonora Lalle | Zendy; Francesca Colavita | Zendy; Andrea Baiocchini | Zendy; Roberta Nardacci | Zendy; Laura Falasca | Zendy; Fabrizio Carletti | Zendy; Eleonora Cimini | Zendy; Licia Bordi | Zendy; Gary Kobinger | Zendy; Valentina D’Ambrosio | Zendy; Fabio Natale | Zendy; Aldo Giancotti | Zendy; Lucia Manganaro | Zendy; Franca Del no | Zendy; Alimuddin Zumla | Zendy; Giuseppina Liuzzi | Zendy; Giuseppe Ippolito | Zendy; Maria Rosaria Capobianchi | Zendy; Chiara Agrati | Zendy; Concetta Castilletti | Zendy

Open Access

Rescue of Replication-Competent ZIKV Hidden in Placenta-Derived Mesenchymal Cells Long After the Resolution of the Infection

Author(s) -

Veronica Bordoni,

Eleonora Lalle,

Francesca Colavita,

Andrea Baiocchini,

Roberta Nardacci,

Laura Falasca,

Fabrizio Carletti,

Eleonora Cimini,

Licia Bordi,

Gary Kobinger,

Valentina D’Ambrosio,

Fabio Natale,

Aldo Giancotti,

Lucia Manganaro,

Franca Del no,

Alimuddin Zumla,

Giuseppina Liuzzi,

Giuseppe Ippolito,

Maria Rosaria Capobianchi,

Chiara Agrati,

Concetta Castilletti

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz342

Subject(s) - zika virus , virology , mesenchymal stem cell , genome , placenta , viral replication , virus , medicine , in vitro , asymptomatic , biology , pregnancy , gene , fetus , pathology , genetics

The Zika virus (ZIKV) genome, its negative-strand viral proteins, and virus-like particles were detected in placenta-derived mesenchymal cells (MSCs), indicating that ZIKV persists after virus clearance from maternal blood and can be rescued by in vitro cultivation. We report for the first time the presence of replication-competent ZIKV in MSCs from an asymptomatic woman who acquired infection during pregnancy.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research