Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus | Zendy

Gilberto A. Santiago | Zendy; Tyler M. Sharp | Zendy; Eli S. Rosenberg | Zendy; Iris Cardona | Zendy; Luisa I. Alvarado | Zendy; Gabriela PazBailey | Zendy; Jorge L. MuñozJordán | Zendy

Open Access

Prior Dengue Virus Infection Is Associated With Increased Viral Load in Patients Infected With Dengue but Not Zika Virus

Author(s) -

Gilberto A. Santiago,

Tyler M. Sharp,

Eli S. Rosenberg,

Iris Cardona,

Luisa I. Alvarado,

Gabriela PazBailey,

Jorge L. MuñozJordán

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz320

Subject(s) - zika virus , dengue virus , dengue fever , virology , medicine , virus , viral infection , viral load

To evaluate potential enhancement of Zika virus (ZIKV) infection among patients with prior dengue virus (DENV) infection, we compared loads of viral RNA among patients infected with ZIKV (n = 1070), DENV-2 (n = 312), or DENV-3 (n = 260). Compared to patients without prior DENV infection, patients with prior DENV infection had significantly higher mean loads of viral RNA if infected with DENV-2 (10.6 vs 11.6 log10 GCE/mL, respectively; t test, P < .0001) or DENV-3 (10.3 vs 10.9 log10 GCE/mL; P < .0001), but not ZIKV (4.7 vs 4.7 log10 GCE/mL; P = .959). These findings provide evidence against in vivo enhancement of ZIKV by anti-DENV antibodies.

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