Syphilis Reactivates Latent Epstein-Barr Virus Reservoir via Toll-Like Receptor 2 and B-Cell Receptor Activation | Zendy

Julia R. Hirsiger | Zendy; P. Fuchs | Zendy; Peter Häusermann | Zendy; Bojana Müller-Durovic | Zendy; Thomas Daikeler | Zendy; Mike Recher | Zendy; Hans H. Hirsch | Zendy; Luigi Terracciano | Zendy; Christoph T. Berger | Zendy

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Syphilis Reactivates Latent Epstein-Barr Virus Reservoir via Toll-Like Receptor 2 and B-Cell Receptor Activation

Author(s) -

Julia R. Hirsiger,

P. Fuchs,

Peter Häusermann,

Bojana Müller-Durovic,

Thomas Daikeler,

Mike Recher,

Hans H. Hirsch,

Luigi Terracciano,

Christoph T. Berger

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz317

Subject(s) - treponema , virology , immunology , medicine , lymphoproliferative disorders , epstein–barr virus , virus , toll like receptor , syphilis , tlr2 , lymphoma , immune system , tlr4 , innate immune system , human immunodeficiency virus (hiv)

Latent Epstein-Barr virus (EBV) infection can clinically reactivate in immunosuppressed individuals causing lymphoproliferative disease and rarely hepatitis. In this study, we provide in vivo and in vitro evidence that Treponema pallidum infection can cause EBV reactivation with hepatitis in an immunocompetent patient. We report the diagnostic challenges and immunological findings of coinciding syphilis and EBV-associated hepatitis. Using an in vitro EBV-reactivation assay, we demonstrate that T pallidum reactivates latent EBV in a Toll-like receptor (TLR)2/B-cell receptor signaling-dependent manner. Epstein-Barr virus-associated reactivation or lymphoproliferation should be considered in infections with pathogens that activate TLR2.

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