The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions | Zendy

Michael H. Woodworth | Zendy; Mary K. Hayden | Zendy; Vincent B. Young | Zendy; Jennie H. Kwon | Zendy

Open Access

The Role of Fecal Microbiota Transplantation in Reducing Intestinal Colonization With Antibiotic-Resistant Organisms: The Current Landscape and Future Directions

Author(s) -

Michael H. Woodworth,

Mary K. Hayden,

Vincent B. Young,

Jennie H. Kwon

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz288

Subject(s) - colonization , fecal bacteriotherapy , colonisation resistance , microbiome , antibiotics , medicine , clostridium difficile , clostridioides , transplantation , intensive care medicine , microbiology and biotechnology , immunology , biology , bioinformatics

The intestinal tract is a recognized reservoir of antibiotic-resistant organisms (ARO), and a potential target for strategies to reduce ARO colonization. Microbiome therapies such as fecal microbiota transplantation (FMT) have been established as an effective treatment for recurrent Clostridioides difficile infection and may be an effective approach for reducing intestinal ARO colonization. In this article, we review the current published literature on the role of FMT for eradication of intestinal ARO colonization, review the potential benefit and limitations of the use of FMT in this setting, and outline a research agenda for the future study of FMT for intestinal ARO colonization.

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