Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia | Zendy

Ella M. Meumann | Zendy; Nicholas M. Anstey | Zendy; Bart J. Currie | Zendy; Kim A. Piera | Zendy; Rob Baird | Zendy; Derek S. Sarovich | Zendy; Joshua S. Davis | Zendy

Open Access

Whole-Genome Sequencing to Differentiate Relapse From Reinfection in Community-Onset Bacteremic Acinetobacter baumannii Pneumonia

Author(s) -

Ella M. Meumann,

Nicholas M. Anstey,

Bart J. Currie,

Kim A. Piera,

Rob Baird,

Derek S. Sarovich,

Joshua S. Davis

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz263

Subject(s) - acinetobacter baumannii , pneumonia , medicine , whole genome sequencing , acinetobacter , bacteremia , genome , microbiology and biotechnology , antibiotics , pseudomonas aeruginosa , gene , biology , bacteria , genetics

Community-onset bacteremic pneumonia recurred in 3 of 30 (10%) patients followed prospectively, all with ongoing hazardous alcohol intake, 3-56 months after initial pneumonia. Paired isolates underwent whole-genome sequencing. Phylogenetic analysis showed that recurrence strains were all distinct from preceding strains, indicating reinfection in susceptible individuals rather than relapse.

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