Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA | Zendy

Maiko Kondo | Zendy; Sudeb C. Dalai | Zendy; Shivkumar Venkatasubrahmanyam | Zendy; Nell Eisenberg | Zendy; Brian D. Robinson | Zendy; Lars F. Westblade | Zendy; Kristen Marks | Zendy

Open Access

Diagnosis and Genotyping of Coxiella burnetii Endocarditis in a Patient with Prosthetic Pulmonary Valve Replacement Using Next-Generation Sequencing of Plasma Microbial Cell-Free DNA

Author(s) -

Maiko Kondo,

Sudeb C. Dalai,

Shivkumar Venkatasubrahmanyam,

Nell Eisenberg,

Brian D. Robinson,

Lars F. Westblade,

Kristen Marks

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz242

Subject(s) - coxiella burnetii , endocarditis , genotyping , medicine , q fever , etiology , microbiology and biotechnology , pathology , surgery , virology , genotype , gene , biology , genetics

Determining the causative etiology of culture-negative endocarditis can be challenging. We performed next-generation sequencing of plasma microbial cell-free DNA to facilitate rapid diagnosis and genotyping of Coxiella burnetii in a patient with culture-negative endocarditis of a prosthetic pulmonary valve, enabling early targeted treatment prior to valve replacement surgery.

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