External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals | Zendy

Sameer S. Kadri | Zendy; Yi Ling Lai | Zendy; Emily Ricotta | Zendy; Jeffrey R. Strich | Zendy; Ahmed Babiker | Zendy; Chanu Rhee | Zendy; Michael Klompas | Zendy; John P. Dekker | Zendy; John H. Powers | Zendy; Robert L. Danner | Zendy; Jennifer Adjemian | Zendy

Open Access

External Validation of Difficult-to-Treat Resistance Prevalence and Mortality Risk in Gram-Negative Bloodstream Infection Using Electronic Health Record Data From 140 US Hospitals

Author(s) -

Sameer S. Kadri,

Yi Ling Lai,

Emily Ricotta,

Jeffrey R. Strich,

Ahmed Babiker,

Chanu Rhee,

Michael Klompas,

John P. Dekker,

John H. Powers,

Robert L. Danner,

Jennifer Adjemian

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz110

Subject(s) - medicine , bloodstream infection , gram , electronic health record , intensive care medicine , health records , emergency medicine , health care , genetics , bacteria , economics , biology , economic growth

Difficult-to-treat resistance (DTR; ie, co-resistance to all first-line antibiotics) in gram-negative bloodstream infection (GNBSI) is associated with decreased survival in administrative data models. We externally validated DTR prevalence and associated mortality risk in GNBSI using detailed clinical data from electronic health records to adjust for baseline differences in acute illness severity.

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