Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease | Zendy

Michael L. Washburn | Zendy; Renae M. Crosby | Zendy; Katja Remlinger | Zendy; Feng Wang | Zendy; Donald Creech | Zendy

Open Access

Therapeutically Attenuating Neutrophil Recruitment With a CXCR2 Antagonist in Combination With Oseltamivir Ameliorates Influenza-Induced Lung Injury and Disease

Author(s) -

Michael L. Washburn,

Renae M. Crosby,

Katja Remlinger,

Feng Wang,

Donald Creech

Publication year - 2019

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofz106

Subject(s) - medicine , oseltamivir , antagonist , lung , immunology , pharmacology , disease , covid-19 , infectious disease (medical specialty) , receptor

Mice were infected with influenza and treated with a CXCR2 antagonist in combination with antiviral or antiviral alone starting 4 days postinfection. Neutrophil recruitment to the lung was reduced, and improvements in health outcomes and lung consolidation were observed in combination-treated mice with no evidence of worsening outcome.

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