The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae | Zendy

Courtney Luterbach | Zendy; Ashley Boshe | Zendy; Heather Henderson | Zendy; Eric Cober | Zendy; Sandra S. Richter | Zendy; Robert A. Salata | Zendy; Robert C. Kalayjian | Zendy; Richard Watkins | Zendy; Andrea M. Hujer | Zendy; Kristine M. Hujer | Zendy; Susan D. Rudin | Zendy; Tatiana Domitrovic | Zendy; Yohei Doi | Zendy; Keith S. Kaye | Zendy; Scott Evans | Zendy; Vance G. Fowler | Zendy; Robert A. Bonomo | Zendy; David van Duin | Zendy

Open Access

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae

Author(s) -

Courtney Luterbach,

Ashley Boshe,

Heather Henderson,

Eric Cober,

Sandra S. Richter,

Robert A. Salata,

Robert C. Kalayjian,

Richard Watkins,

Andrea M. Hujer,

Kristine M. Hujer,

Susan D. Rudin,

Tatiana Domitrovic,

Yohei Doi,

Keith S. Kaye,

Scott Evans,

Vance G. Fowler,

Robert A. Bonomo,

David van Duin

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy351

Subject(s) - carbapenem resistant enterobacteriaceae , medicine , trimethoprim , enterobacteriaceae , carbapenem , sulfamethoxazole , microbiology and biotechnology , pathogenic organism , enterobacteriaceae infections , antibiotics , escherichia coli , biology , biochemistry , gene

In the Consortium on Resistance Against Carbapenems in Klebsiella and other Enterobacteriaceae (CRACKLE), trimethoprim-sulfamethoxazole (TMP-SMX) had a limited role in the treatment of less severe carbapenem-resistant Enterobacteriaceae (CRE) infections, especially urinary tract infections. Of tested CRE, only 29% were susceptible to TMP-SMX. Development of resistance further limits the use of TMP-SMX in CRE infections.

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