Randomized Controlled Pilot Study of Antiretrovirals and a Behavioral Intervention for Persons With Acute HIV Infection: Opportunity for Interrupting Transmission | Zendy

William C. Miller | Zendy; Sarah E. Rutstein | Zendy; Sam Phiri | Zendy; Gift Kamanga | Zendy; Dominic Nsona | Zendy; Dana K. Pasquale | Zendy; Katherine B. Rucinski | Zendy; Jane S. Chen | Zendy; Carol E. Golin | Zendy; Kimberly A. Powers | Zendy; Ann M. Dennis | Zendy; Mina C. Hosseinipour | Zendy; Joseph J. Eron | Zendy; Wairimu Chege | Zendy; Irving Hoffman | Zendy; Audrey Pettifor | Zendy

Open Access

Randomized Controlled Pilot Study of Antiretrovirals and a Behavioral Intervention for Persons With Acute HIV Infection: Opportunity for Interrupting Transmission

Author(s) -

William C. Miller,

Sarah E. Rutstein,

Sam Phiri,

Gift Kamanga,

Dominic Nsona,

Dana K. Pasquale,

Katherine B. Rucinski,

Jane S. Chen,

Carol E. Golin,

Kimberly A. Powers,

Ann M. Dennis,

Mina C. Hosseinipour,

Joseph J. Eron,

Wairimu Chege,

Irving Hoffman,

Audrey Pettifor

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy341

Subject(s) - medicine , randomized controlled trial , psychological intervention , cohort , transmission (telecommunications) , viral load , intervention (counseling) , incidence (geometry) , human immunodeficiency virus (hiv) , immunology , psychiatry , physics , electrical engineering , optics , engineering

Diagnosis of AHI facilitates behavioral and biomedical risk reduction strategies during a high-transmission period that begins years before people are typically identified and started on ARVs. Sexually transmitted infection incidence in this cohort suggests ongoing risk behaviors, reinforcing the importance of early intervention with ARVs to reduce transmission. Early diagnosis coupled with standard AHI counseling and early ARV referral quickly suppresses viremia, may effectively change behavior, and could have tremendous public health benefit in reducing onward transmission.

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