Procalcitonin-Guided Antibiotic Therapy Reduces Antibiotic Use for Lower Respiratory Tract Infections in a United States Medical Center: Results of a Clinical Trial | Zendy

Jennifer Townsend | Zendy; Victoria Adams | Zendy; Panagis Galiatsatos | Zendy; David B. Pearse | Zendy; Hardin Pantle | Zendy; Mary Masterson | Zendy; Flora Kisuule | Zendy; Elsen Jacob | Zendy; Catherine Kiruthi | Zendy; Paúl Ricaurte Ortiz | Zendy; Albert Agbanlog | Zendy; Robert Jurao | Zendy; Sam Stern | Zendy; Seema Nayak | Zendy; Michael Melgar | Zendy; Jacob Sama | Zendy; Jillian Irwin | Zendy; Cyrus Mazidi | Zendy; Kevin J. Psoter | Zendy; Robin McKenzie | Zendy

Open Access

Procalcitonin-Guided Antibiotic Therapy Reduces Antibiotic Use for Lower Respiratory Tract Infections in a United States Medical Center: Results of a Clinical Trial

Author(s) -

Jennifer Townsend,

Victoria Adams,

Panagis Galiatsatos,

David B. Pearse,

Hardin Pantle,

Mary Masterson,

Flora Kisuule,

Elsen Jacob,

Catherine Kiruthi,

Paúl Ricaurte Ortiz,

Albert Agbanlog,

Robert Jurao,

Sam Stern,

Seema Nayak,

Michael Melgar,

Jacob Sama,

Jillian Irwin,

Cyrus Mazidi,

Kevin J. Psoter,

Robin McKenzie

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy327

Subject(s) - medicine , antibiotics , procalcitonin , adverse effect , pneumonia , respiratory tract infections , intensive care medicine , lower respiratory tract infection , exacerbation , sepsis , respiratory system , microbiology and biotechnology , biology

A PCT-guided algorithm safely reduced the duration of antibiotics for treating LRTI. Utilization of a PCT algorithm may aid antibiotic stewardship efforts.This clinical trial was a single-center, controlled, pre-post study of PCT-guided antibiotic therapy for LRTI. The intervention (incorporation of PCT-guided algorithms) started on April 1, 2017: the preintervention (control group) comprised patients admitted from November 1, 2016 to April 16, 2017, and the postintervention group comprised patients admitted from April 17, 2017 to November 29, 2017 (Supplementary Figure 1). The study comprised patients admitted to the internal medicine services to a medical ward, the Medical Intensive Care Unit (MICU), the Cardiac Intensive Care Unit (CICU), or the Progressive Care Unit (PCU) "step down unit". The registration data for the trails are in the ClinicalTrials.gov database, number NCT0310910.

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