Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak | Zendy

Francesca Colavita | Zendy; Serena Vita | Zendy; Eleonora Lalle | Zendy; Fabrizio Carletti | Zendy; Licia Bordi | Zendy; Donatella Vincenti | Zendy; Irene Pozzetto | Zendy; Massimo Aiuti | Zendy; Francesco Vairo | Zendy; Maria Rosaria Capobianchi | Zendy; Miriam Lichtner | Zendy; Concetta Castilletti | Zendy

Open Access

Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak

Author(s) -

Francesca Colavita,

Serena Vita,

Eleonora Lalle,

Fabrizio Carletti,

Licia Bordi,

Donatella Vincenti,

Irene Pozzetto,

Massimo Aiuti,

Francesco Vairo,

Maria Rosaria Capobianchi,

Miriam Lichtner,

Concetta Castilletti

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy276

Subject(s) - chikungunya , outbreak , medicine , virus , virology , cytokine storm , interferon , disease , immunology , cytokine , alphavirus infection , infectious disease (medical specialty) , covid-19

Chikungunya fever is caused by Chikungunya virus (CHIKV) and is generally considered a self-limiting disease. However, severe clinical presentations with a high mortality rate have been reported in association with underlying medical conditions. This study reports the molecular characterization of the virus and an abnormal pattern of circulating cytokines in a unique lethal CHIKV case during the 2017 outbreak in Italy, which involved an elderly patient with underlying cardiac disease. Analysis of inflammatory cytokines revealed a strong increase of interferon (IFN)-α and IFN-β, as well as interleukin-6, suggesting a possible role of type-I IFN in the cytokine storm, which may be correlated with unfavorable prognosis of CHIKV infection.

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