Validation of an Antimicrobial Stewardship-Driven Verigene Blood-Culture Gram-Negative Treatment Algorithm to Improve Appropriateness of Antibiotics | Zendy

Kimberly C. Claeys | Zendy; Kathryn Schlaffer | Zendy; Emily L. Heil | Zendy; Surbhi Leekha | Zendy; J. Kristie Johnson | Zendy

Open Access

Validation of an Antimicrobial Stewardship-Driven Verigene Blood-Culture Gram-Negative Treatment Algorithm to Improve Appropriateness of Antibiotics

Author(s) -

Kimberly C. Claeys,

Kathryn Schlaffer,

Emily L. Heil,

Surbhi Leekha,

J. Kristie Johnson

Publication year - 2018

Publication title -

open forum infectious diseases

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.546

H-Index - 35

ISSN - 2328-8957

DOI - 10.1093/ofid/ofy233

Subject(s) - medicine , antimicrobial stewardship , antibiotics , bacteremia , algorithm , gram , antibiotic stewardship , blood culture , stewardship (theology) , intensive care medicine , antibiotic therapy , antimicrobial , microbiology and biotechnology , antibiotic resistance , bacteria , genetics , politics , computer science , law , political science , biology

Rapid diagnostic testing (RDT) allows for early adjustment of antibiotic therapy. This study examined the potential impact of a stewardship-driven antibiotic treatment algorithm, incorporating RDT into the management of Gram-negative bacteremia. The proposed algorithm would have resulted in 88.4% of cases receiving appropriate antibiotic therapy versus 78.1% by standard of care ( = .014).

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