Open AccessCFTR Heterozygotes Are at Increased Risk of Respiratory Infections: A Population-Based Study
Author(s) -
Philip M. Polgreen,
Grant Brown,
Douglas B. Hornick,
Ferhaan Ahmad,
Barry London,
David A. Stoltz,
Alejandro P. Comellas
Publication year - 2018
Publication title -
open forum infectious diseases
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.546
H-Index - 35
ISSN - 2328-8957
DOI - 10.1093/ofid/ofy219
Subject(s) - medicine , heterozygote advantage , pathogenic organism , population , compound heterozygosity , respiratory tract infections , cystic fibrosis , respiratory system , intensive care medicine , microbiology and biotechnology , genotype , environmental health , genetics , mutation , gene , biology
Patients heterozygous for mutations are at higher risk for respiratory infections. Future work to describe clinical outcomes for heterozygotes is needed.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom