425. Chikungunya in Solid-Organ Transplant Recipients, a Case Series and Literature Review

Background Chikungunya virus is a recent emerging arbovirus in Latin America. Clinical manifestations can vary from fever and rash to severe chronic inflammatory arthritis. Few reports have been published regarding this infection in immunocompromised patients, including in solid-organ transplant (SOT) recipients. Methods We presented a case series of SOT recipients with confirmed Chikungunya infection by positive RT-PCR (LightMix® kit Chikungunya-virus, Light Cycler® Roche Diagnostics), during the 2015 epidemic in Colombia. In addition, we conducted a literature review, searching PUBMED, EMBASE, LILACS regarding Chikungunya infection in SOT recipients. Results Ten SOT recipients were included (five kidneys, four liver, and one liver/kidney transplant). The mean age of the transplant recipients was 47 years, 70% were women. The most frequent symptoms were arthralgia and fever. None of the patients required treatment in the intensive care unit; no fatal cases or graft rejection were reported. None of our patients had recurrent arthritis during the three months follow-up. In the literature review, we found 21 cases reported. All of them had a benign clinical course with no severe complications or death. No chronic inflammatory arthritis cases were reported. Conclusion CHIK infection in SOT recipient have a benign course, and have no chronic recurrent arthritis. We proposed that immunosuppression could decrease the risk of severe or chronic inflammatory manifestations. Disclosures All authors: No reported disclosures.